Silymarin is widely consumed by people with chronic HCV or HIV. Some of the cytoprotective effects include blocking hepatitis C virus, inhibiting cellular pathways, blocking virus-induced oxidative stress, and by blocking t-cell proliferation and pro-inflammatory cytokines production. Silymarin and silybins also rapidly induce various cellular stress responses resembling energy and nutrients stress.Scientist use IPA to collect, test and interpret biological data. Ingenuity Pathway Analysis (IPA) is a web-based functional analysis tool for comprehensive omic data. The IPA steps include generating data, performing basic statistics, using query ingenuity knowledge base, analyze affected biology, and analyze visual data in context. (http://norris.usc.libguides.
What is interesting is that according to WebMD, “It’s unclear what benefits, if any, this may have in the body.” They say this and then explain that, at this point there is not enough evidence to suggest whether or not milk thistle (silymarin) helps with liver problems but continue to suggest that it does benefit those with diabetes and those with potential heart diseases. As far as side effects are concerned, it can cause diarrhea, nausea, bloating, gas and an upset stomach. It seems to me that more research needs to be done before people make an uneducated assumption that it is working for them. Especially since Dr. Polyak mentioned that oral silymarin is ineffective. It upsets me that people are given the option to buy over-the-counter milk thistle if it does not improve their health in the way they think it does.
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