There are different types of
penicillin and used to treat different kinds of infections, such as skin
infections, dental infections, ear infections, respiratory tract infections,
urinary tract infections, gonorrhea, and other infections caused by bacteria.
These drugs isnot effective for colds,
flu, and other infections caused by viruses. Examples of penicillins are
penicillin V (Beepen-VK, Pen-Vee K, V-cillin K, Veetids) and amoxicillin
(Amoxil, Polymox, Trimox, Wymox). Penicillins may be mix with other ingredients
called beta-lactamase inhibitors, which protect the penicillin from bacterial
enzymes that may destroy it before its function. Thus, penicillins are obtained
via prescription.
The original form of penicillin is
called penicillin G. It is a narrow-spectrum antibiotic, which can be destroyed
by stomach acid, but it is still useful against anaerobic bacteria. Newer
penicillins are resistant to stomach acid, such as penicillin V, or have a
broader spectrum, such as ampicillin and amoxicillin.
Penicillins are effective against
infections in many parts of the body, including the mouth and throat, skin and
soft tissue, tonsils, heart, lungs, and ears. However, since many bacteria are
resistant to penicillin, it is often wise to do a culture and sensitivity test
before using penicillin. In some cases, there are only a few types of bacteria
that are likely to be a problem, and so it is appropriate to use penicillin
without testing. For instance, dentists often prescribe penicillin to prevent
infections after dental surgery.
Penicillins are usually very safe
and the greatest risk is an allergic reaction, which can be severe. People who
have been allergic to cephalosporins are likely to be allergic to penicillins.
Moreover, people with certain medical conditions or who are taking certain
other medicines can have problems if they take penicillin.
In conclusion, penicillin is a compound with three chiral center and the stereochemistry is as follows:
The carbon labeled 2 is S, carbon labeled 5 is R and carbon labeled 6 is S.
shouldnt the number of chiral centers be 3 ,
ReplyDeleteas nitrogen is also a chiral center in the figure..??
Why nitrogen is not considered as chiral center
ReplyDelete