Amoxicillin
Given my particular interest in medicinal chemistry, amoxicillin seemed a good choice as one of my favorite organic molecules given its use as an antibiotic. I find it a particularly interesting molecule given the presence of the benzene and beta lactam ring.
Formula: C16H19N3O5
-Functional groups present:
· *Phenol
· *Primary amine (basic
group)
· *Secondary amine
· *Carboxylic acid
(acidic group)
Amoxicillin was discovered in 1972
in Beecham Research Laboratories (UK). It was discovered in an attempt to find derivatives
of penicillin that could treat a wider range of infections. This led to the
discovery of ampicillin followed by amoxicillin.
It is synthesized from naturally occurring substances as shown below:
2-2-(4-hydroxyphenyl)glycine trimethylsylil ester of 6-APA
chloride hydrochloride
amoxicillin
It
is an antibiotic used to fight bacteria and bacterial infections. The walls
surrounding the bacteria are prevented from forming due to the presence of the
amoxicillin and therefore the bacteria can no longer multiply.
Examples
of bacterial infections that can be treated with amoxicillin are…
Streptococci,
E. coli, Staphylococcus, H. pylori, P. mirabilis, H. influenzae, N. gonorrhoeae, and S. pneumonia.
It is due
to the discovery of molecules such as amoxicillin that today we can enjoy the
effective treatments of many bacterial infections.
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